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NAD + boosters can be applied for a broad spectrum of NAD + deficiency related pathologies, such as infection, cancer, metabolic diseases, acute injury, aging and aging-related neurodegenerative disorders

This process triggers a potent inflammatory response, characterized by the upregulation of pro-inflammatory cytokinesincluding IL-1 and interferon- (IFN-)and the concomitant downregulation of tight junction proteins, thereby compromising mucosal barrier integrity 76

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KPV may be a more effective and targeted means of reducing inflammation in IBD via its effects on TNF-alpha, but without affecting TNF-alpha in other locations of the body