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Additionally, they point out that hyperhomocysteinemia remains an independent risk factor for thrombosis and stroke after adjustment for established risk factors

Niedernhofer LJ, Essers J, Weeda G, Beverloo B, de Wit J, Muijtjens M et al

Disruption of this homeostatic equilibrium can lead to dysbiosis and consequent metabolic perturbations that are increasingly implicated in the pathogenesis of chronic conditions such as cancer, cardiometabolic disorders, and IBD (187)

In this context, the exploration of ME/CFS pathogenesis has increasingly focused on the microbiome-gut-brain axis, revealing a complex interplay between intestinal dysbiosis and the multifaceted symptomatology of this debilitating condition [10]