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This commonly includes lifelong treatment for pernicious anaemia, managing severe B12 deficiency with neurological symptoms to prevent further damage, and for individuals post-gastric surgery due to impaired absorption

In addition, treatment effects estimated using MMRM analyses are typically larger than those seen with MI analyses since the MMRM estimates the treatment effect while participants are adhering to the investigational drug, whereas MI-based estimates (reflecting the intent-to-treat approach) are irrespective of adherence

Published safety profile remained clean Phase IIb: Larger cohort, confirmed dose-response

Example: A note stating "injection administered in the right thigh" helps clarify the documentation