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Arsenic has been shown to interfere with glucocorticoid and thyroid hormone signaling, while lead exposure has been associated with altered reproductive hormone levels and impaired feedback mechanisms in the hypothalamicpituitarygonadal axis [85]

10.1161/JAHA.118.010069 97

When administered directly into the affected joint or spine area, corticosteroids can: Reduce inflammation around the bone spur Alleviate pain by decreasing the inflammatory response Improve joint function and range of motion Provide relief from symptoms for several weeks to months Corticosteroids are particularly beneficial for patients who have not responded adequately to other forms of treatment, such as physical therapy or nonsteroidal anti-inflammatory drugs (NSAIDs)

10.1007/978-94-007-6627-3_4 Adv Exp Med Biol