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Indeed, nitrated aSyn is almost exclusively found in the insoluble protein fraction making aSyn more resistant to degradation, more compact, and more stable 112,113

Studies have examined its effects on cellular proliferation, differentiation, and metabolic activity across a range of cell culture models, including myoblast and osteoblast systems

However, if it fails to receive all four electrons and was only partially reduced, this outcome will generate free radicals resulting in oxidative stress, or an imbalance between the formation of ROS and antioxidants (Figure 2)

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