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Biological Activity NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 M), selectively binding to NNMT substrate binding site residues

These patients often require therapeutic doses under medical supervision

The challenge, as we will see in the clinical evidence section, is translating that theoretical appeal into measurable real-world results at a magnitude that matters

While there isnt solid evidence that human requirements for B12 exceed the RDA, meeting the EFSA will put any vegan on par with most omnivores and should ensure optimal B12 status for anyone without suspected abnormal B12 metabolism