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When Not to Use Eflornithine Known hypersensitivity to eflornithine or cream excipients Broken, inflamed, or infected skin in the application area Children ( 6 months: Continue maintenance if satisfied

In the production of cosmetics, due to its complete water solubility, it is extremely convenient to add and non-irritating, making it suitable for sensitive skin

List of samples used in genomic analyses are included in Supplementary Data 1 and Supplementary Data 2

MTHFR protein exists as a homodimer comprising two N-terminal catalytic domains with binding sites for NADPH, methylene-THF, and cofactor FAD-linked to the regulatory domain (C-terminus) (Figure 2B)