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The inconsistency likely arises from differences in experimental conditions, such as pH, Cu+/Cu2+ ratio, A isoform, and the presence of reducing agents or cofactors (190)

Among these, we focused on miR-1297 for further investigation

There is a vast amount of evidence that mitochondrial dysfunction occurs after the early cellular events in AD and can contribute to the advancement of further degeneration, but it is often unclear whether mitochondrial dysfunction is indeed just a secondary event or whether it might be involved in primary pathogenesis

Our experts have compiled a list of effective strategies to eliminate it once and for all