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As the purpose of the intra-luminal guidance is to direct the axon growth cone across the gap, once the first axons have bridged the gap, the presence of intraluminal guidance is no longer necessary and its degradation provides more space to fill by the native ECM [51]

However, in diabetic wounds, the transition from M1 to M2 is disrupted, leading to the accumulation of M1 macrophages, which produce ROS and sustain long-term inflammation