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Melatonin reverses the doxorubicin-induced upregulation of ACSL4 and downregulation of GPX4 and yes-associated protein 1 (YAP1)

Luxembourg: Office for Official Publications of the European Communities

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Conclusion: Here we report a novel function of portal fibroblasts as drivers of cholestatic fibrosis, ductular reaction, inflammation, hepatocyte senescence, and HCC in aged mice, demonstrating the key role of the tumor microenvironment