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These data point to a previously unrecognized effect of KG-mediated epigenetic rewiring through histone acetylation

Itoigawa et al

Evidence for peroxisomal dysfunction and dysregulation of the CDP-choline pathway in myalgic encephalomyelitis/chronic fatigue syndrome

By conducting in-depth analysis of the diet-microbiota-immunometabolism regulatory network, through targeted dietary modifications to adjust nutrient availability in the TME, reshaping the gut microbiota with probiotics or prebiotics to enhance immunometabolic activity, and combining immune checkpoint inhibitors with metabolism-targeted drugs, it may be possible to disrupt tumor metabolic adaptation and immune escape at a systemic level, thereby achieving personalized and precision therapy