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In glaucoma, alterations in the ON head due to increased IOP also include reduced blood flow, oxidative stress, reactive gliosis, as well as remodeling of the extracellular matrix (Howell et al., 2007

Tenner L, Hlubocky FJ, Blanke CD, LeBlanc TW, Marron JM, McGinnis MM, Spence RA, Taylor LP

Amazon and other E-platforms, could, by being more vigilant, by consulting government, academic and civil society websites, and by due diligence in enforcing their own policies, better protect consumers from the health risks associated with SLPs

however, issues such as drug toxicity and prolonged treatment durations highlight the urgent need for more effective alternatives