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Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models

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In senescent cells, this selectively causes p53 nuclear exclusion and cell-intrinsic apoptosis

Some patients choose morning injections to maintain injection day awareness and avoid forgetting doses, while others prefer evening timing because nausea (a common early side effect) occurs while they sleep