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Int J Mol Med (2017) 40(6):186980

Some of these chelating agents have been reported to lighten the pigmentation in small skin areas after intradermal injection, particularly sodium thiosulfate and potassium ferrocyanide, but results are inconsistent, and their application to larger areas would be quite incommodious and burdensome, with the risks associated far outweighing the unlikely benefits [19,55,131,178,245]