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Kim et al summarized that PFE inhibited the adhesion and migration of endometriotic cells and suppressed the establishment of ectopic endometrial lesion tissue by downregulating MMP-2 and MMP-9 levels, and by regulating the ERK1/2 signaling pathway

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Together, providing the innate harmful effect of NOS blocker L-NAME itself, these findings may emphasize the positive significance of NO in protecting retinal neurons (and thereby, harmful effect of NOS-blockers ( Furthermore, it was demonstrated that NO is continuously produced in the retina and essential for maintenance of retinal blood flow (Vukojevic et al., 2018