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PCD: programmed cell death

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Hormones like GH and IGF1 activate the related pathways by binding to their cognate receptors can decrease the sensitivity to irradiation and increase the expression levels of ataxia telangiectasia mutated (ATM), H2AX, p53BP-1, catalytic subunits of the DNA-dependent protein kinase (DNA-PKcs) and PARP-1 that related to the DNA repair function ( In this review, we summarized the studies on GH-IGF1 signaling in the development of cancer, the resistance effects of radiotherapy in the treatment of cancer, and the repair of adjacent tissues after radiotherapy