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Splenic sequestration occurs when the spleen enlarges (for example, due to cirrhosis of the liver or certain types of leukemia) and captures, or sequesters, more platelets from the circulation than normal

It is often found in individuals with autoimmune disorders, particularly lupus, but can also occur in individuals without a known autoimmune condition

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The combination of these two peptides creates a frequently used research tool to study the molecular mechanisms of tissue repair, anti-inflammatory processes, and muscle adaptation