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90,91,92,93,94 In corneal injury, LPA triggers HB-EGF shedding, which activates EGFRERKAkt signaling to promote epithelial repair

Key compounds such as withaferin A, withanolide A, and withanosides have demonstrated antioxidant, anti-inflammatory, neuroprotective, immunomodulatory, and anticancer activities

Longevity protocol: Dose: 0.5-1mg daily (lower end) Frequency: 3-5 times weekly Cycle: 8 weeks on, 4 weeks off, indefinite repetition Combine with: Overall health optimization (sleep, nutrition, exercise) Lower doses for longevity reduce cost and theoretical concerns about long-term copper peptide use while potentially maintaining meaningful benefits

Therefore many of the novel functions associated with these enzymes can be exploited for development of therapeutics to combat human diseases