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Additionally, data from a Phase I clinical trial (NCT02861300) indicated that the combination of CB-839 and capecitabine which is a prodrug of 5-FU, was well tolerated by CRC patients at bioactive doses

These studies suggest that increasing ROS levels in PCa cells may offer a promising therapeutic strategy by promoting prostate cell death

For twice-daily injections, administer once in the AM and once in the PM

In acute ANIT model and Mdr2-/- model, the serum ALT of HLX92 was over 2 times less than cholestatic control, which also showed superior efficacy in ameliorating liver injury to UDCA and OCA