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2.1 Molecular mechanisms of Sunitinibs anti-tumor activity in RCC Sunitinib is classified as a multi-targeted TKI that inhibits angiogenesis and tumor growth by targeting tyrosine kinase (RTK) receptors, including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), cellular homolog of the v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene (c-Kit/kit), and FMS-like tyrosine kinase 3 (FLT3) (Sweeney et al., 2023) (Figure 1)

Co-administration of HAART and antikoch triggers cardiometabolic dysfunction through an oxidative stress-mediated pathway

Given the intricate association between lactate metabolism and the progressive growth and proliferation of various malignancies, HATs have emerged as prime therapeutic targets for the treatment of cancerous disorders

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