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This aspect is, indeed still mysterious even if a protein with CAT feature has been described in the nuclear extract from HEK293 cells (Madiraju et al., 2009)

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It is also important to note that a prior randomized, placebo-controlled, double-blind study of LAC treatment for probable AD patients showed that administration of LAC was associated with lower AD-related deterioration as assessed using the clinical dementia rating scale and mini-mental scale examination in those subjects younger than 65 years [65, 66]