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For the primary CosMx experiment, 22 FOV were selected, five were ultimately eliminated due to poor tissue adherence or low gene count per cell

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This increase in fission, however, has a protective effect in this context because it sensitizes ectopic endometrial cells to apoptosis by promoting release and activation of the mitochondrial serine protease HtrA2/Omi, which cleaves and inactivates inhibitor-of-apoptosis proteins (IAPs), thereby weakening a major anti-apoptotic defense and reducing lesion invasion and migration ( 4.3 Mitochondrial autophagy and endometriosis Mitochondrial autophagy, or mitophagy, is a highly selective, damage-responsive clearance process that identifies, labels, and removes dysfunctional, depolarized, or aged mitochondria while preserving the healthy mitochondrial network

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