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In clinical trials, a single oral dose of macimorelin (0.5 mg/kg) was shown to be reliable and accurate for diagnosing adult GHD (49)

Am J Pathol 140:691707 Schiffer D, Cordera S, Cavalla P, Migheli A (1996) Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis

The highest rates are observed among patients with prosthetic valves, intracardiac devices, unrepaired cyanotic congenital heart diseases, or a history of infective endocarditis