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10.1021/acsomega.3c05537 132

(More information) I3C and DIM have been found to modulate the expression and activity of biotransformation enzymes that are involved in the metabolism and elimination of many biologically active compounds, including steroid hormones, drugs, carcinogens, and toxins

Notably, the crystal structure revealed that the G-loop gate and inner helix gate are too constricted to conduct hydrated K + ions, suggesting the channel in the presence of PIP 2 is closed in this structure (Whorton and MacKinnon, 2011)

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