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Electrographic abnormalities are also seen, specifically epileptiform-like spikes in the hippocampus, neocortex, and basal ganglia, with discharges in the basal ganglia associated with measurable extrapyramidal behavioral abnormalities (194)

While biotransformation processes based on petrochemical achiral precursors have been described for bacterial hosts, fermentative de novo synthesis has not been established although it holds the potential for a sustainable and economical one-pot process using renewable feedstocks

DOI: 10.3389/fphar.2020.599721