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First-Pass effect

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Commenters noted that removing the physician order requirement alleviates a long-standing barrier to hepatitis B vaccine coverage

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Azithromycin may elevate serum digoxin levels

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M1 macrophages metabolize arginine to nitric oxide (NO) and citrulline with high levels of iNOS, while M2 macrophages metabolize arginine to ornithine and polyamines via enzyme arginase, ornithine decarboxylase, and spermidine oxidase (102)

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