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Ain-Shams J Anesthesiol 15 , 7 (2023)

It is involved as 5-methyl tetrahydrofolate methionine in the methylation process where the methyl group is transferred to homocysteine to form methionine in the presence of methionine synthase enzyme

Besides in vitro cell culture models, organoids and simpler organisms, such as invertebrates, have been suggested to avoid classical animal testing with rodents or other mammals