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Current experiments rely on SOD1 transgenic models, which do not recapitulate mitochondrial complex IV deficiency or the genetic heterogeneity of sporadic ALS (such as C9orf72 repeat expansion) and do not assess spinal cord targeting or pharmacokinetic limitations of ferroptosis inhibitors, including low solubility and short half-life

doi: 10.1016/0891-5849(95)00017-R 150 RahimlouMAsadiMBanaei JahromiNMansooriA

The Wegovy dosage schedule is as follows: You might stay on a lower dose for longer, such as if you get side effects that youd rather have settled before you continue with a higher dose

Samples with any sign of hemolysis are not acceptable for this assay