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These results indicated that gingerols and shogaols have immunomodulatory activity by decreasing the production of COX-2 and proinflammatory cytokines and the release of histamine, and they reduced the severity of inflammatory disorders

It catalyzes the reduction of ferric iron (Fe 3+ ) in MetHb back to Fe 2+ , preserving hemoglobins oxygen-carrying ability and preventing NO-induced inactivation (Rahaman et al., 2017