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doi:10.1042/BCJ20160103 23 Nguyen TL, Durn RV

The second reduces the accumulation of AGEs in human tissues by catabolizing and removing the generated AGEs (61)

Additionally, a 2021 investigation showed that Metformin may help protect against macular degeneration in older adults, while a 2022 study suggested that Metformin may reduce the need for joint replacement

However, excessive maternal caffeine exposure (100 mg/kg/day, intraperitoneally) during pregnancy has been indicated in inducing cataracts (130), suggesting that caution when consuming a high quantity caffeine is necessary for pregnant women