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177,178 Copper also activates the interaction between HIF-1 and hypoxia-responsive elements as well as the HIF1-Snail/Twist signaling pathway, promoting the development of EMT

*Correspondence: Weina Li, [email protected] Meng Li, [email protected] These authors have contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Abstract Myelin, the membrane surrounding neuronal axons, is critical for central nervous system (CNS) function

Urine organic acid analysis has historically been performed using GC/MS instrumentation