how is glutathione used in the er ER-phagy drives resistance to mitochondria-targeted therapy breast cancer Role of Glutaredoxin-1 and Glutathionylation

High expression of GPX3 and MYC was significantly enriched in interferon-/ responses and TNF-/NF-B signaling pathways, whereas low expression was enriched in metabolic pathways such as fatty acid metabolism, bile acid metabolism, and oxidative phosphorylation

This results in the precise, reversible oxidation of key regulatory nodes, exemplified by the transient inhibition of protein tyrosine phosphatase 1B (PTP1B), which allows for the activation of kinase-driven pathways like insulin signaling [122]

Thus, they can affects body in different arrays of their mode of action

Bardellini E, Veneri F, Amadori F, Conti G, Majorana A