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AMT lacks receptor specificity, which increases the off-target distribution 118,119

Mitofusins, from mitochondria to metabolism

NPs allow precise delivery of the CRISPR/Cas9 components to neurons, allowing for accurate gene editing and potential disease modification (153)

Because sulfoxide metabolites are more potent nephrotoxicants than their parent S -conjugates, more research is needed on the extent of formation of S -(1,2-dichlorovinyl)-L-cysteine and N -acetyl- S -(1,2-dichlorovinyl)-L-cysteine sulfoxides by human tissues (liver and kidney), the extent to which these reactions occur in vivo, the enzymes involved, and their interindividual variability, including the role of genetic polymorphisms