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Het werd oorspronkelijk ontdekt in menselijk maagsap en trok aandacht vanwege mogelijke therapeutische effecten, met name bij herstel van het maag-darmkanaal en wondgenezing

Two possible scenarios were considered to explain the distinct appearance of cyanobacterial nozzles: either the physiological structures are monomeric rings, and the observed dimers formed during isolation, or the nozzles function as dimers, indicating a plasticity in certain secretins to adopt novel structural arrangements

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THP-1 cells are usually treated with phorbol 12-myristate 13-acetate (PMA) in order to differentiate them into macrophages (Riendeau and Kornfeld, 2003)