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Angiopep-2, the ligand of the low-density lipoprotein receptor-related protein enhanced the BBB transcytosis of star-shaped, multibranched poly(l-glutamic acid) nanoconjugates in animals [50]

In addition, apoptosis also plays a role in the development of brain tumors such as glioblastoma, and its defects may lead to the development of brain cancer, and the different morphological and biochemical characteristics of apoptosis pathways are closely related to the regulation of cell death (Figure 2)

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Persistent elevations in blood glucose activate several interconnected biochemical and molecular pathways, including the polyol pathway, the formation of AGEs, activation of protein kinase C, the hexosamine biosynthetic pathway, excessive oxidative stress, and epigenetic modifications