glutathione s-transferases resistance Frontiers Frontiers | Glutathione-the “master” antioxidant

A gene ontology enrichment analysis (ToxoDB) of the 249 proteins decreased in abundance indicated that proteins involved in translation (59 proteins, 6.31-fold enrichment, p-value 2.5 x 10 -33 ), ribosome biogenesis (10 proteins, 3.93-fold enrichment, p-value 1.78 X 10 -4 ), DNA replication (9 proteins, 4.39-fold enrichment, p-value 1.59 x 10 - 4 ), DNA replication initiation (6 proteins, 16.26-fold enrichment, p-value 3.34 x 10 -7 ) and DNA dependent DNA replication (6 proteins, 8.61-fold enrichment, p-value 3.73 x 10 -5 ) were significantly enriched in our dataset

Swedish Metabolomics Centre, Ume, Sweden (www.swedishmetabolomicscentre.se) is acknowledged for help with methodology standadization and quantification of pyroglutamic acid Kynurenine and tryptophan by LC-MS

Dungubat E, Watabe S, Togashi-Kumagai A, Watanabe M, Kobayashi Y, Harada N, et al

In some embodiments, the cell is a macrophage subtype, e.g., a macrophage subtype described herein