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Yilmaz and Oner found lower plasma melatonin levels in COVID-19-positive pneumonia patients compared to healthy controls at 23:00 h and compared to the COVID-19-negative pneumonia group and healthy controls at 02:00 h and 06:00 h

doi: 10.3389/fvets.2020.00412 68

Thiamin homeostasis in the central nervous system

Depression ALCAR shows promise in treating depression, with research dating back to the 1990s highlighting antidepressant-like effects through modulation of neurotransmitter systems [5]