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Increased oxidative stress and disrupted small intestinal tight junctions in cigarette smoke-exposed rats

The Pro-fibrotic Milieu When examined in animal models, wound healing processes and fibrotic responses are characterized by type 2-like environment governed by the presence of IL-4, IL-13, ILC2, Th2-like T cells, and M2 macrophagesalso named alternatively activated macrophagesall discussed in following paragraphs [87,88,89]