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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)

Following the clinical success with maraviroc, other CCR5 antagonists are in development, showing potential not only as HIV entry inhibitors but also as therapeutics for certain inflammatory diseases 106,114118