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( Although lithiums prevention of neuro-inflammation may simply represent one of the multi-faceted mechanisms by which GSK-3 inhibition protects neurons, the above evidence also suggests that TLR4 is a direct target for lithium, upstream of GSK-3 (see Figure 1B)

(Reference Brondani, Assmann, de Souza, Boucas, Canani and Crispim25,Reference Zahedi, Djalalinia and Sadeghi26) We conducted subgroup analyses, to identify potential sources of heterogeneity considering some important variables including baseline body mass index (BMI (kg/m 2 )), health condition of participants, type of green tea, study location, green tea dosage (mg/ day), duration of intervention (weeks), and gender

10.1016/0304-4157(86)90006-7 190 RappaportS

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