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The research reveals that GHK-Cu modulates the NAD-dependent deacetylase sirtuin-1 (SIRT1) and the signal transducer and activator of transcription 3 (STAT3) signaling pathway

The GSH/GSSG ratio in the cytoplasm varies between 30/1 to 100/1, whereas in the endoplasmic reticulum (ER) is between 3/1 and 1/1, which indicates that in ER the system GSH/GSSH is more oxidized than that from the cytoplasm