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Regulation of preproinsulin mRNA stability in health and diabetes Preproinsulin mRNA has a long half-life, which is mainly regulated by a conserved polypyrimidine tract and a UUGAA-motif in its 3-UTR [13, 16]

These metabolic states appear to be related to the divergent functions of FoB and MZB, which have been documented in numerous studies 7,8,9,10,11,12,13,14