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Results Protein glutathionylation is widely identified across the proteome We have taken advantage of advancements in LC sensitivity, MS instrumentation and data processing workflows 22,23 , as well as developments in High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) 24 , to develop an enrichment- and label-free methodology for the identification of glutathionylation on a global scale (Figure 1A) We initially subjected human osteosarcoma (U2OS) cells to our workflow and identified 22, 8, 13 and 16 cysteine -palmitoyl, -nitrosyl, -cysteinyl and -carbamyl PTMs respectively, as well as 898 cysteine glutathionylation sites corresponding to 565 proteins

NCOA4 can mediate ferritinophagy, while it is degraded via HERC2 ubiquitination-mediated induction of the proteasomal degradation machinery in the presence of iron ( FBXL5 E3 ubiquitin ligase mediated ubiquitination and proteasomal degradation ( Both, iron deficiency and iron overload lead to impaired hematopoietic functions

Cancer Metastasis Rev 25: 387408, review

Identification and antibiotic susceptibility of bacterial isolates from probiotic products