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Notably, although Diquat has been banned in regions such as the European Union and the United Kingdom due to its ecological toxicity and health risks (EC Regulation No 1107/2009), it is still used for weed control in agriculture and non-cultivated land in certain developing countries

85,86 The potent vasoconstrictor 20-HETE is also affected by COX-2 inhibition as it is at least partially inactivated by a COX-2-dependent metabolic step