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For example, electrophiles such as sulforaphane and tert-butyl hydroquinone (tBHQ) can covalently modify these cysteine residues, leading to conformational changes in Keap1 [23]

Astrocytes play a key role in the development, maintenance, and function of the blood-brain barrier (BBB), and BBB dysfunction has been observed in SCZ patients (Stanca et al., 2024

Here we show that low levels of cystine and thiols in CSF create a pro-oxidative environment and enhanced susceptibility to lipid peroxidation, revealing a niche-dependent metabolic vulnerability of ALL cells residing in the leptomeninges