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doi: 10.1016/j.clml.2011.07.001 52 GuYYuanY-HXuJShiQ-LQuX-YGuoRet al

Moreover, excessive APAP increases hepatic CXCL16 levels, CXCL16 deficiency significantly reduces the production of pro-inflammatory cytokines TNF- and IL-6, and inhibits neutrophils migration to the site of injury, other chemokines CXCL1 and CXCL2 expression are also diminished, suggesting that CXCL16 may be involved in neutrophil infiltration in APAP hepatotoxicity [38]