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In diabetes, prolonged hyperglycemia induces oxidative stress in ulcerated tissues, leading to the depletion of glutathione (GSH), a key precursor for GPX4 synthesis

To determine whether the prolonged blood circulation time might increase their distribution in other organs, saline and A2-APM (Cy7.5-labeled aPD-L1, aPD-L1 equivalent dose 1.5 mg/kg) were intravenously given to C57 mice bearing GL261 and G422 tumors

Normally distributed data were examined with Levenes test to evaluate the homogeneity of variances between groups

The use of oral or topical glutathione depends on the requirements and advice of healthcare professionals