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*Correspondence: Pedro Grandes, [email protected] These authors have contributed equally to this work and share last authorship This article was submitted to Nutrition, Psychology and Brain Health, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

NNMT (nicotinamide N-methyltransferase) is a cytosolic enzyme that catalyzes a specific methylation reaction: it transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing two products 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

If your body doesnt produce enough intrinsic factor, it can become B12 deficient

64 SileikyteJ.Blachly-DysonE.SewellR.CarpiA.MenaboR.Di LisaF.et al (2014)