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Inflammatory cytokines including tumor necrosis factor alpha (TNF), interferon gamma (IFN), and interleukin-1 beta (IL-1), cause beta-cell dysfunction by impairing ATP production, inducing DNA damage, and promoting apoptosis ( Figure 3 ) (84, 85)

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Dalf E, Portero-Otn M, Ayala V, Martnez A, Pamplona R, Ferrer I

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Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNF killing by inducing IKK--SSG formation, leading to suppressed NF-B activation

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