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5 GCN5L in cell stress responses The cellular stress response is a series of physiological and biochemical reactions that cells activate to maintain cellular homeostasis and viability when faced with stressful conditions such as oxidative stress, endoplasmic reticulum stress, metabolic stress, heat stress, and nutrient deprivation

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Mol Pharmacol 69:650657 Buer CS, Kordbacheh F, Truong TT, Hocart CH, Djordjevic MA (2013) Alteration of flavonoid accumulation patterns in transparent testa mutants disturbs auxin transport, gravity responses, and imparts long-term effects on root and shoot architecture

These combined effects lead to the abnormal accumulation of unfolded or misfolded proteins, ultimately inducing ERS